Large packet loss outside my home network

I am experiencing severe, sustained packet loss of over 70% specifically when routing to target servers.

Target destination:  50.228.250.250

I have run a traceroute and PingPlotter diagnostic. My local home network is completely clear, but data is collapsing at the Comcast handoff node right after the Microsoft edge network. I need this escalated to network engineering to check for a regional routing or peering issue.