POP3 vs. IMAP

Well I encounter any problems if I set up my Outlook 365 email using POP3? I have no reason to want to synchronize my email and folders over several devices and I would prefer not to have my information stored on the XFINITY "cloud". Also, I would like to delete my incoming mail as soon as it has been downloaded to my desktop. As I understand it, I cannot do this using IMAP.