Emails won't send

Having a recurring issue with emails not being able to send and getting error message: (451 - 451 4.2.0 QRHZwSTp6HvE9QRHZwkeGJ policy violation, try again later (DFTD)
).

I am using a supported browser. The total number of recipients is less than 100. I'm only trying to send 3 separate emails to around 80 recipients each give or take and not exceeding 1000 recipients per day. And the message is not too large, only around 300KB. I am able to send the first 2 emails successfully and then run into this issue with the final email significantly hindering important communications for my business. Please help.