Domain being throttled

I'm the Email Admin for a reputable domain that is being throttled. We are receiving this error message "[Edited: "Personal Information"] delayed. Reason: 4.3.2 - Not accepting messages at this time ('421', ['4.1.0 162.129.199.120 Throttled - try again later. Please see https://postmaster.comcast.net/smtp-error-codes.php#RL000003'" We have several gateways and all messages are being DKIM signed, we have DMARC and SPF records published as well. The IP addresses for there gateways have been around over 20+ years. An are now experineing this issue. We are a Hospital and University an need some assistance to reduce the throttling. Already check the postmaster.comcast.net site it didnt help.