..."I figured out that the cable box only becomes unresponsive when I'm watching one particular channel (HSN) I also realized that the Guide button will still work (but not any of the number buttons or the channel up/down button) so I can change the channel that way. "... I too have recently observed this change in STB behavior. If I stop on HSN for more than a couple of seconds, it locks up and I can not change the channel and must power the STB off or use the Guide/Menu/VOD buttons to get the remote going again. I've got a DCH3200. My guess it is a programming change made by Comcast for their remote shopping feature and it was not properly tested.
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